معرفی
Xilin Shen is a Research Scientist in the Department of Radiology & Biomedical Imaging at the Yale School of Medicine. He holds a PhD from the University of Colorado at Boulder (2007). His research focuses on neuroimaging techniques including functional MRI (fMRI), calcium imaging, and brain connectivity analysis, with applications in Alzheimer’s disease, bipolar disorder, and neurodevelopmental disorders. Collaborators include Todd Constable, Xenophon Papademetris, and Evelyn Lake. He has published extensively on topics such as functional connectome fingerprinting, aging-related brain connectivity changes, and multimodal neuroimaging techniques.
- Education: PhD in Neuroscience/Imaging Sciences from University of Colorado Boulder (2007)
Key research interests include understanding brain network organization across different states (e.g., wakefulness, anesthesia), developing predictive models for mental health conditions using functional connectivity, and translating animal models (e.g., mouse studies) to human neurodegenerative diseases. Recent work highlights the use of fMRI and calcium imaging to study synaptic plasticity in Alzheimer’s models and the role of mGluR5 modulators in reversing connectivity deficits.
Publications span over 15 years, emphasizing methodological advancements in neuroimaging analysis and their clinical applications. Notable contributions include demonstrating individualized brain connectivity fingerprints and identifying sex differences in aging brain networks.