معرفی
Francesca Mandino is an Associate Research Scientist in the Department of Radiology & Biomedical Imaging at Yale School of Medicine. Her research focuses on neuroimaging methodologies, functional connectivity analysis, and neurological disorders such as Alzheimer’s disease, autism spectrum disorders, and hydrocephalus. She employs advanced MRI techniques and animal models to study brain dynamics and neural networks.
Her work emphasizes translational research, integrating multimodal imaging (e.g., fMRI, calcium imaging) with genetic and behavioral studies. Key projects include investigating CSF dynamics in neurodevelopmental disorders, developing consensus protocols for rodent neuroimaging, and exploring synaptic changes in traumatic brain injury. Collaborations with experts like Evelyn Lake, Xilin Shen, and Michael Crair highlight interdisciplinary approaches to understanding brain function and disease.
Publications span topics like Alzheimer’s pathology reversal via mGluR5 modulators, anesthesia effects on neuroimaging, and the role of PTEN mutations in cortical circuitry. Her studies often utilize mouse models to bridge preclinical findings with clinical insights.
Dr. Mandino’s contributions advance neuroimaging standards and uncover mechanisms underlying cognitive and neurological disorders, with implications for diagnostic and therapeutic strategies.
