معرفی
Xiaowei Zhuang is a Chinese-American biophysicist and the David B. Arnold Jr. Professor of Science at Harvard University, where she holds joint appointments in the Department of Chemistry and Chemical Biology and the Department of Physics. She is also an Investigator at the Howard Hughes Medical Institute, contributing significantly to advanced bioimaging technologies.
- Education: B.S. in Physics (University of Science and Technology of China, 1991); Ph.D. in Physics (University of California, Berkeley, 1996)
- Postdoctoral: Chodorow Postdoctoral Fellow at Stanford University (1997–2001)
Renowned for inventing STORM (Stochastic Optical Reconstruction Microscopy), Zhuang’s research has revolutionized super-resolution fluorescence microscopy by overcoming diffraction limits. Her lab develops innovative single-molecule imaging techniques, including MERFISH (Multiplexed Error-Robust Fluorescence In Situ Hybridization), enabling precise spatial transcriptomics and cellular structure visualization. Current work spans 3D chromatin organization, tumor-immune interactions, and neural circuit mapping.
The 15 most recent publications highlight her lab’s expertise in super-resolution imaging, spatial transcriptomics, chromatin dynamics, neurobiology, and cancer-immune crosstalk. These works demonstrate cross-disciplinary applications from single-molecule biophysics to clinical oncology.
- Scientific Awards: Breakthrough Prize in Life Sciences (2019), Vilcek Prize (2020), Heinrich Wieland Prize (2022), MacArthur Fellow (2003), NAS Award in Molecular Biology (2015)
- Academic Recognition: Member of National Academy of Sciences (2012), American Philosophical Society (2019), and Chinese Academy of Sciences (2015)
Zhuang’s laboratory at Harvard has trained prominent researchers like Dr. Melike Lakadamyali and continues advancing single-virus tracking, live-cell imaging, and cellular structure analysis. Her work bridges physics, chemistry, and biology to address fundamental biological questions through technological innovation.
