معرفی
Xi Chen, Ph.D., is Professor of Biostatistics in the Department of Public Health Sciences at the University of Miami Miller School of Medicine. He directs the Biostatistics and Bioinformatics Shared Resource and heads the Translational Statistical Bioinformatics Laboratory, driving integrated data-science approaches to cancer and Alzheimer’s disease research.
Education
- 2006 – Ph.D. in Statistics, North Carolina State University
- 2004 – M.S. in Statistics, North Carolina State University
- 2002 – M.S. in Molecular Genetics, North Carolina State University
- 1999 – B.S. in Biochemistry, Lanzhou University
Research Interests
Dr. Chen’s work bridges advanced statistical methodology and high-throughput genomic data to tackle complex biomedical questions. Major foci include:
- Translational cancer research, especially biomarker discovery in triple-negative breast and colorectal cancers.
- Multi-omics integration—combining genomics, epigenomics, proteomics, and methylomics for systems-level insights.
- Predictive modeling and high-dimensional variable selection for precision medicine.
- Epigenomic signatures of aging and Alzheimer’s disease, leveraging large longitudinal cohorts.
His lab develops reproducible computational tools and collaborates closely with bench scientists and clinicians to translate statistical findings into clinical impact.
Recent Publication Trends
Over the last two years Dr. Chen’s publications reveal a strategic expansion from foundational cancer genomics toward neuroepigenomics. Cutting-edge methylation-array quality control studies complement the creation of the MIAMI-AD knowledgebase, underscoring his commitment to open, integrative resources. Ongoing work on blood-based dementia biomarkers and lifestyle-resilience signatures illustrates the translational arc of his research program.
Scientific Awards & Honors
While the provided text does not enumerate specific awards, Dr. Chen has served as a reviewer for numerous prestigious panels including:
- National Cancer Institute Cancer Biomarker Study Section (CBSS)
- National Institute of Neurological Disorders & Stroke (NINDS)
- Morris K. Udall Centers of Excellence for Parkinson’s Disease Research (P50)
- Health and Medical Research Fund, Government of Hong Kong
Grants & Collaborations
Dr. Chen has directed multiple NIH-funded projects integrating gene expression, proteomic, and methylation data to identify actionable cancer biomarkers. His interdisciplinary teams include oncologists, pathologists, and computational biologists across the University of Miami and external consortia.
Laboratory & Teams
The Translational Statistical Bioinformatics Laboratory (tsblab.org) provides a collaborative hub where trainees and staff develop next-generation analytical pipelines. The lab maintains active GitHub repositories and openly shares software tools to foster reproducible research in the genomics community.
