معرفی
Tuoqi Wu is an Assistant Professor in the Department of Immunology at UT Southwestern Medical Center, Dallas, TX. He is also a member of the Harold C. Simmons Comprehensive Cancer Center. Previously, he held an Assistant Professor position in the Department of Immunology and Microbiology at the University of Colorado School of Medicine (2019-2021), alongside memberships in the Human Immunology and Immunotherapy Initiative and University of Colorado Cancer Center. His expertise bridges immunology and molecular biology with a focus on T-cell functionality in chronic infections and cancer.
Dr. Wu earned a dual Bachelor of Science degree in Biotechnology and Computer Science from Peking University in 2007. He completed his Ph.D. in Biological and Biomedical Sciences at Emory University (2013) under Dr. Rafi Ahmed in the Department of Microbiology and Immunology. Postdoctoral training at NIH (2013-2019) further refined his research skills in immunological mechanisms.
His research investigates molecular pathways governing CD8+ T-cell differentiation, exhaustion, and stemness using cutting-edge techniques like single-cell transcriptomics and epigenomics. Key areas include STING signaling, KEAP1/NRF2 redox regulation, and BACH2/FOXP1 transcriptional control. Applications span antiviral immunity, cancer immunotherapy (CAR T cells), and immune checkpoint blockade efficacy in melanoma.
Recent publications highlight T-cell immune landscapes in cancer patients, aging effects on cytotoxic T-cells, and computational tools like Benisse for B-cell analysis. His work emphasizes translating molecular insights into clinical immunotherapies to improve treatment outcomes.
No scientific awards were mentioned in the provided text. His advising includes PhD students Ziang Zhu (focused on T-cell immunology) and Safuwra Wizzard (clinically oriented research). Postdoctoral researchers Ying Luo and Taidou Hu contribute expertise in T-cell exhaustion and epigenetic regulation. Grant funding details are not included here, though institutional memberships suggest active research support.
Dr. Wu leads the Wu Lab at UTSW, a multidisciplinary team exploring T-cell biology, CAR T-cell engineering, and immune dysfunction in chronic diseases. The lab’s work integrates experimental immunology with bioinformatics to address unresolved challenges in antitumor and antiviral immunity.
