معرفی
Dr. Scott McComb is an Adjunct Professor at the Department of Biochemistry, Microbiology and Immunology within the Faculty of Medicine at the University of Ottawa. Concurrently, he serves as a Research Officer in the Cancer Immunology Team at the National Research Council of Canada's Human Health Therapeutics division. His research focuses on improving CAR-T cell therapy for cancer through genome editing and understanding immune cell life/death mechanisms.
- Current academic affiliation: University of Ottawa (Faculty of Medicine)
- Research expertise: Cancer Immunology, Programmed Cell Death, CAR-T Therapy
- Email: scott.mccomb@nrc-cnrc.gc.ca
Dr. McComb's work combines in vitro and in vivo approaches with human primary immune cell differentiation studies to analyze cellular immunotherapy dynamics. His recent publications highlight molecular insights into apoptosis/necroptosis regulation and interferon signaling pathways.
Key research themes include:
- CRISPR-based genome editing for T-cell enhancement
- Targeting programmed cell death in immunotherapy
- Mechanistic analysis of immune signaling pathways
- Development of multi-targeted immunotherapies
- Mouse models for cancer therapy validation
- Human immune cell functional assays
