معرفی
William S. Bush, PhD, is Professor in the Department of Population and Quantitative Health Sciences and Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, serving as Associate Director for Computational Genomics at the Institute for Computational Biology. His research integrates functional genomics knowledge into genetic analysis and leverages electronic medical records for translational applications in neurocognitive disorders.
Education:
- PhD, Vanderbilt University, 2008
- MS, Vanderbilt University, 2008
Dr. Bush specializes in bioinformatics and statistical methods development for detecting complex genetic effects, knowledge-guided genomic analysis using structured biological hypotheses, and genetic epidemiology of Alzheimer's Disease and HIV-associated neurocognitive disorders. His work emphasizes nuclear and mitochondrial genetic interactions and pathway-based analytical approaches.
His 2019-2020 publications reveal strong focus on Alzheimer's disease genomics through large consortia like the Alzheimer's Disease Sequencing Project, with significant contributions to software engineering for reproducible bioinformatics, pathway analysis methodologies, and multi-ethnic genomic studies. Key themes include immune pathway involvement in neurodegeneration and translational applications of genomic data.
Scientific Awards: None listed in source materials.
Dr. Bush mentors Master's students, PhD candidates, and postdoctoral fellows while leading major NIH-funded initiatives:
- NIH/NIA RO1: Genetic drivers of resilience to Alzheimer’s disease
- NIH/NIGMS RO1: Atlas of clinical associations mapping to protein structures
- NIH/NIA UO1: Alzheimer’s Disease sequence analysis collaborative
- USDA/Foundation for Food and Agriculture Research: Modeling neighborhood food futures
- NIH/NIDDK U2: Cleveland KPMP recruitment network
- NIH/NIAID R56: Genetics of TB resistance in HIV+ subjects
- NIH/NIA U54: Alzheimer’s Disease Sequencing Project coordination
- NIH/NIA U01: Replication of ADSP discoveries in African-Americans
- NIH/NIA R01: Genetics of Alzheimer Disease in Puerto Ricans
He co-chairs the ADSP Annotation Working Group, develops widely used genomic annotation resources, and holds external appointments at Cleveland Clinic Genomic Medicine Institute and Cleveland Institute for Computational Biology.
