Wiebke Albrecht

Dr. Wiebke Albrecht is a Scientific Associate in Systems Toxicology at the Leibniz Research Centre for Working Environment and Human Factors (IfADo) in Dortmund, Germany, affiliated with Technical University of Dortmund. She works under Prof. Dr. Jan G. Hengstler's leadership with contact information listed as +49 231 1084-431 and albrecht@ifado.de. Her research focuses on hepatotoxicity prediction, drug-induced liver injury mechanisms, and development of in vitro testing methodologies for toxicological assessment.

Dr. Albrecht's research interests center on systems toxicology approaches to understanding hepatotoxicity mechanisms. She investigates drug-induced liver injury (DILI), develops predictive models for toxicological risk assessment, and studies interspecies differences in toxin metabolism. Her work integrates experimental toxicology with computational approaches to improve in vitro testing systems' accuracy and reliability. Specific areas include bile acid effects on cytotoxicity, steatosis prediction methods, and gene expression analysis for toxicity classification.

Analysis of Dr. Albrecht's publication trends reveals consistent focus on improving hepatotoxicity prediction methods and understanding liver injury mechanisms. Her work spans from fundamental research on toxin metabolism across species to developing practical testing protocols. A notable trend is integrating high-throughput gene expression data with traditional cytotoxicity assays to create robust predictive models. Her research addresses critical challenges like interspecies extrapolation, concentration optimization for in vitro testing, and developing human-relevant liver toxicity models.

Dr. Albrecht actively participates in numerous collaborative research projects, working with scientists across German institutions and internationally. Her extensive publication record suggests substantial research funding support, though specific grant details aren't provided in the text. She contributes significantly to the EU-ToxRisk project as evidenced by her 2020 publication on method documentation for regulatory use of new approach methods.

As part of the Systems Toxicology team at IfADo, Dr. Albrecht utilizes advanced methodologies including intravital imaging, HPLC-MS/MS analysis, and computational modeling. The institute's facilities include animal laboratories, bioanalytical units, and outpatient departments that support her research on hepatotoxicity mechanisms and prediction methods.