Reham Hassan Reyad Khalil Alkashef

Dr. Reham Hassan Reyad Khalil Alkashef is a Scientific Associate in the Intravital Toxicology department at the Institute for Work Physiology (IFADO) at Technische Universität Dortmund. She works under the leadership of Prof. Dr. Jan G. Hengstler and specializes in advanced toxicological research using intravital imaging techniques to study liver toxicity, drug metabolism, and interspecies differences in toxic responses.

Her primary research interests include:

• Intravital imaging of toxicological processes
• Drug-induced liver injury and mechanisms
• Bile acid transport and metabolism
• Mycotoxin (ochratoxin A, AFB1) metabolism and toxicity
• Species differences in toxicological responses
• Liver-kidney axis in toxicology
• Spatiotemporal distribution of toxins

Dr. Alkashef's publication record demonstrates extensive work on liver toxicity mechanisms, with particular emphasis on acetaminophen-induced injury, bile acid homeostasis, and mycotoxin metabolism. Her research integrates intravital imaging with analytical techniques like HPLC-MS/MS to provide comprehensive understanding of toxicokinetics and toxicodynamics. Recent publications show her active role in developing liver digital twins for in silico toxicity testing and investigating the liver-kidney axis in cholestatic conditions.

Her research has significant implications for drug safety assessment, understanding species differences in toxic responses, and developing strategies to mitigate drug-induced organ damage. She frequently collaborates with interdisciplinary teams including computational biologists, hepatologists, and pharmacologists to advance the field of toxicology.