Patrick Nell

Dr. Patrick Nell serves as Junior Group Leader of the Regulatory Networks of Stem Cell Differentiation research group at the Leibniz Research Centre for Working Environment and Human Factors (IfADo) at TU Dortmund University since 2022, operating within the Toxicology department under Department Head Prof. Dr. Jan G. Hengstler.

His academic training includes a B.Sc. in Biology with medical specialization from Radboud University Nijmegen (2009-2014), an M.Sc. in Molecular and Developmental Stem Cell Biology from Ruhr University Bochum/Tongji University Shanghai (2014-2016), and a Ph.D. in Stem Cell Technology, Liver Physiology, and Transcriptional Regulatory Networks from IfADo (2016-2021).

Nell's research centers on stem cell differentiation mechanisms, particularly using iPSC-derived hepatocyte-like cells to model liver development, toxicity, and disease. His work integrates transcriptomics, regulatory network analysis, and bile acid metabolism to develop advanced in vitro testing systems for toxicology, with emphasis on endocrine disruptors, cholestatic injury, and liver-intestine crosstalk.

His 14 publications (2018-2025) reveal consistent focus on stem cell-based toxicology models, including studies on bisphenols, parabens, and bile acid transporters. Key contributions include biomarker discovery for hepatotoxicity, FXR-modulated hybrid cell states, and roadmaps for regulatory acceptance of stem cell testing methods.

The Regulatory Networks of Stem Cell Differentiation group employs stem cell engineering, transcriptomics, and bioinformatics to advance predictive toxicology models and regenerative medicine applications, maintaining strong collaborations across international research networks.