معرفی
Wesley I. Sundquist is Distinguished Professor and Chair of the Department of Biochemistry at the University of Utah School of Medicine. He is also a member of both the Molecular Biology Program and the Biological Chemistry Program.
Education:
- B.A. – Carleton College
- Ph.D. – Massachusetts Institute of Technology
Research Interests:
Dr. Sundquist’s laboratory uses viruses as model systems to illuminate fundamental cell biology. His work focuses primarily on:
- HIV replication and integration, dissecting how the viral capsid orchestrates reverse transcription and nuclear import.
- ESCRT-mediated membrane remodeling, revealing how the ESCRT pathway drives viral budding, cytokinetic abscission, and nuclear envelope resealing.
- Cytokinetic abscission checkpoint, investigating how cells delay completion of cell division in response to mitotic errors.
- Synthetic biology, engineering de novo protein nanocages that can be secreted within extracellular vesicles.
Publication Trends:
Between 2015 and 2021 Dr. Sundquist’s group published extensively on ESCRT structure and mechanism, HIV capsid biology, and the intersection between viral and cellular membrane dynamics. Cryo-electron microscopy and biochemical reconstitution are recurring methodological themes that underlie these studies.
Scientific Recognition:
While no specific awards are enumerated in the provided text, his designation as a Distinguished Professor recognizes sustained high-impact contributions to his field.
Laboratory & Mentorship:
The Sundquist laboratory is described as a rigorous, supportive, creative, diverse, and inclusive environment that trains graduate students and postdoctoral fellows in cutting-edge molecular, structural, and synthetic biology approaches.
