Wen Wu

Wen Wu is an Assistant Professor in Chemical and Pharmaceutical Biology at the University of Groningen's Faculty of Science and Engineering. His research focuses on CRISPR-Cas systems, protein engineering, high-throughput screening, and synthetic biology with applications in genome editing.

His investigations center on CRISPR enzyme mechanisms, including Cas12 variants and TnpB enzymes, exploring their evolutionary pathways and potential biotechnology applications. Research spans structural characterization, functional analysis, and development of novel genome editing tools.

Publications demonstrate consistent focus on CRISPR systems from structural analysis to application development. Recent work includes CRISPR-Cas12 characterization, transposon-associated enzymes, and miniature effectors for transcriptional control. Articles appear in Nature, Nature Structural & Molecular Biology, and Nucleic Acids Research.