معرفی
Wen Jiang is the Dorothy Foehr Huck and J. Lloyd Huck Chair in Structural Biology and Professor of Biochemistry & Molecular Biology at Penn State University. He leads the Jiang Lab, specializing in cryo-EM structural biology, biophysics computing, and in situ structural techniques like CLEM and electron tomography. His research focuses on amyloids, viruses, and protein complexes, alongside methodological advancements in cryo-EM sample preparation and data analysis.
Education: B.S. in Physics (Peking University), M.S. in Biophysics (Chinese Academy of Sciences), Ph.D. and postdoc in Cryo-EM (Baylor College of Medicine under Prof. Wah Chiu).
Research interests include structural studies of neurodegenerative disease-related amyloids, viral structures, and the development of computational tools for cryo-EM (e.g., Helicon, CryoVR). The lab collaborates across disciplines, welcoming candidates in biology, physics, engineering, and computer science.
Prominent software contributions include MotionCorr enhancements, jspr for image processing, and web apps like map2seq and ProCart. Alumni have transitioned to roles at institutions like NIH, HHMI Janelia, and industry positions in biotechnology.
Key lab activities include cryo-EM methodology, viral vaccine design using pseudoviruses, and structural studies of bacterial enzymes and viral capsids. Collaborations focus on applying cryo-EM to biomedical challenges like neurodegeneration and infectious diseases.
