معرفی
Wayne A Hendrickson is a University Professor and Violin Family Professor of Physiology and Cellular Biophysics at Columbia University, with a dual appointment in the Department of Biochemistry and Molecular Biophysics. He serves as Scientific Director of the New York Structural Biology Center and leads a research laboratory focused on atomic-level structural analysis of biological macromolecules.
- Education: BA in Physics and Biology (University of Wisconsin at River Falls), PhD in Biophysics (Johns Hopkins University)
- Research: Structural biology of membrane receptors, viral proteins, molecular chaperones, and structural genomics
His methodological innovations in anomalous scattering, stereochemically restrained refinement, and synchrotron instrumentation have transformed structural biology. Current projects investigate transmembrane signal transduction (especially GPCRs), HIV envelope glycoprotein dynamics, and protein folding mechanisms using hybrid approaches combining X-ray crystallography, cryo-EM, and biochemical analyses.
Article trends reveal sustained contributions to
- multiwavelength anomalous diffraction (MAD) techniques
- conformational heterogeneity in proteins
- atomic resolution of medically relevant targets
Scientific Awards
- Ewald Prize (2023) - highest honor in crystallography
- Canada Gairdner International Award (2003)
- Gregori Aminoff Prize (1997) - Royal Swedish Academy
As principal investigator, he has mentored numerous researchers including graduate student Guanqi Lu. His lab at Columbia's Hammer Building (HHSC 510) develops integrated structural workbench tools and maintains active collaborations with Brookhaven National Laboratory's synchrotron facilities.
