معرفی
Dr. Warren L. Lee holds a Canada Research Chair in Mechanisms of Endothelial Permeability and is affiliated with the University of Toronto and Ryerson University. He is based at the Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, where his lab investigates vascular barrier regulation. His academic credentials include an MD from the University of Toronto (Cody Gold Medal) and a PhD in Cell Biology from the Hospital for Sick Children (2006).
- Residency in Internal Medicine, Respirology, and Critical Care Medicine (Toronto)
- Postdoctoral training in Microbiology and Immunology at Weill Medical College of Cornell University
Research Focus: Dr. Lee's lab examines two critical vascular permeability pathways: paracellular leakage in inflammatory conditions like sepsis/influenza and transcellular transcytosis in atherosclerosis. Key innovations include:
- Developing TIRF microscopy assays for LDL transcytosis
- Identifying SR-BI receptor's role in lipid transport
- Pioneering Tie2 agonist therapy for influenza vascular leakage
- Exploring microbubble/ultrasound techniques for drug delivery
Scientific Contributions: His work has been recognized through:
- Canada Research Chair (2016)
- Global Health Care Innovation Academy 3rd Prize (2018)
- The Lung Association – Pfizer Research Award (2016-2017)
- Ontario Early Researcher Award (2011-2016)
Lab Environment: The Lee Lab fosters a collaborative culture through weekly lab meetings and journal clubs, with additional multidisciplinary engagement via joint floor meetings at St. Michael’s Hospital.
