معرفی
Jiwon Lee serves as the Ralph and Marjorie Crump Assistant Professor of Engineering at Dartmouth College's Thayer School of Engineering, leading innovative research in antibody repertoire profiling, systems immunology, and vaccine design to combat infectious diseases through engineered immunotherapies.
Education:
- BA in Molecular & Cell Biology, University of California, Berkeley (2009)
- PhD in Chemical Engineering, University of Texas, Austin (2016)
Her laboratory pioneers high-throughput proteomic technologies and computational modeling to dissect antibody responses at mucosal sites and systemic circulation. This systems immunology approach integrates protein engineering with clinical insights to develop precision vaccine strategies against influenza, SARS-CoV-2, and bacterial pathogens, emphasizing translational applications for vulnerable populations including the elderly and cystic fibrosis patients.
Analysis of her 11 publications (2016-2022) reveals a cohesive trajectory in humoral immunity research, with seminal work on cross-reactive coronavirus antibodies, egg-adapted influenza vaccine limitations, and age-related immune responses. Her studies consistently bridge computational biology and clinical immunology to identify protective antibody features for next-generation vaccine development.
Key recognitions:
- Neukom Award for outstanding research innovation
- Neukom Institute CompX Faculty Grant (2022) supporting cancer immunotherapy development
Professor Lee actively mentors PhD candidates including Nicholas Curtis and Steven Ionov (whose cystic fibrosis/COVID-19 research earned a Scientific Merit Award), while guiding recent graduates like Meredith. Her lab receives strategic funding through Dartmouth's Cancer Accelerator program and NIH-affiliated research initiatives.
The Lee Lab operates across Dartmouth's Engineering and Computer Science Center and Dartmouth-Hitchcock's Williamson Translational Research Building, fostering collaborations between engineers, immunologists, and clinicians to accelerate therapeutic discovery.
