Vijay Ramani

Vijay Ramani is an Assistant Professor at the University of California San Francisco (UCSF), affiliated with the Gladstone Institute for Data Science & Biotechnology and the Department of Biochemistry and Biophysics. His research focuses on developing genome-scale methods for studying chromatin structure and transcriptional regulation in mammalian systems.

• Primary Thematic Area: Human Genetics
• Secondary Thematic Area: Cancer Biology & Cell Signaling

His lab pioneers techniques like single-cell Hi-C, MNase-SSP, and proximity ligation for RNA structure analysis, enabling high-resolution mapping of 3D genome organization and gene expression dynamics. Collaborative work spans single-cell multiomics, chemical transcriptomics, and chromatin accessibility studies.

Key methodologies include:

• Single-molecule oligonucleosome footprinting
• DNase Hi-C for 3D genome mapping
• Chemical transcriptomics at single-cell resolution
• Joint chromatin/gene expression profiling