Valerie O'Donnell

Professor Valerie O'Donnell is a distinguished academic at Cardiff University's School of Medicine, where she serves as Professor of Biochemistry and Co-Director of the Systems Immunity Research Institute (SIURI), established in 2016 with £4.5M funding. She leads the internationally recognized LIPID MAPS project (www.lipidmaps.org) and Cardiff Lipidomic Facility, positioning her at the forefront of lipidomics research. With over two decades of academic leadership, she previously served as Director of the Division of Infection and Immunity (2017-2020) and Dean of Research for the School of Medicine (2012-2014).

Professor O'Donnell earned her Ph.D. in Biochemistry from the University of Bristol (1990-1993) working with Prof. OTG Jones and Dr. PJ England of SmithKline Beecham Pharmaceuticals, following her B.Sc. in Human Nutrition & Dietetics (Hons. 2.1) from University of Dublin, Trinity College, Ireland (1985-1989). Her academic journey includes prestigious fellowships at the University of Alabama at Birmingham and University of Bern, Switzerland, before establishing her career at Cardiff University.

Her research focuses on using mass spectrometry to discover and characterize bioactive lipids made by circulating vascular cells that regulate immune defense and blood clotting. Over the past 20 years, her lab discovered large families of enzymatically-oxidized phospholipids (eoxPL) and has worked extensively on their structures, signaling actions in thrombosis and innate immunity. Current research examines the role of bioactive lipids in vascular inflammation including abdominal aortic aneurysm, cardiovascular disease, dementia and wound healing.

Analysis of her recent publications reveals a strong emphasis on lipidomics methodology development, clinical applications of lipid research, and the role of specific lipids in disease mechanisms. Her work spans analytical chemistry, cardiovascular biology, immunology, and clinical translation, with particular focus on procoagulant lipids, oxylipins, and specialized pro-resolving mediators. The research demonstrates increasing interdisciplinary collaboration and methodological standardization efforts in the lipidomics field.

Professor O'Donnell's scientific achievements have been recognized with numerous prestigious awards:

• 2023: Honorary Officer of the Order of the British Empire (OBE) for services to biochemical research
• 2020: Fellow of the Academy of Medical Sciences
• 2019: Journal of Lipid Research Lectureship Award
• 2016: Wolfson Research Merit Award, Royal Society
• 2015: Fellow of the Learned Society of Wales
• 2013: Fellow of the Royal Society of Biology

She currently serves as Principal Investigator for British Heart Foundation and Wellcome Trust funding, while also participating as co-Investigator for Medical Research Council (MRC), EU (Marie Curie ITN), and Welsh Government projects. Her panel memberships include Population Systems Medicine Board (MRC) and Biomedical Resources Committee (Wellcome Trust). With a Google Scholar H-index of 52, she has been included in UK national research assessments RAE2002, RAE2008, and REF2014.

Professor O'Donnell leads the Systems Immunity Research Institute, a strategic research institute at Cardiff University, and directs the Cardiff Lipidomic Facility as part of the LIPID MAPS consortium. Her laboratory continues to make significant contributions to understanding how bioactive lipids regulate vascular inflammation and coagulation, with recent work focusing on the role of specific phospholipids in conditions ranging from cardiovascular disease to SARS-CoV-2 infection. In 2024, LIPID MAPS became an ELIXIR Core Data Resource and a member of the Global Biodata Coalition, with an MRC Partnership Grant commencing funding.