Tristan Shuman

Tristan Shuman, PhD is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai, where he also serves as Co-Director of the Center for Computational and Systems Neuroscience. His laboratory is housed in the Hess CSM Building (Room 10-301) at 1470 Madison Avenue in New York City.

Dr. Shuman earned his PhD in Experimental Psychology from the University of California, San Diego, where he investigated how addiction-related memory ensembles contributed to cocaine drug seeking. He then completed postdoctoral training at the University of California, Los Angeles, examining network alterations in epileptic mice before joining the Mount Sinai faculty.

His research program focuses on understanding how the brain produces precise neural activity for memory tasks and how these processes break down in neurological diseases. The Shuman Lab specializes in using in vivo calcium imaging with miniature microscopes and electrophysiology with silicon probes to investigate network alterations in mouse models of epilepsy and Alzheimer's disease. His team has made significant contributions to understanding how abnormal circuit processing leads to cognitive deficits and seizures, with particular emphasis on hippocampal and entorhinal cortex function.

Analysis of Dr. Shuman's publication record since 2018 reveals a strong focus on neural circuit mechanisms in epilepsy and Alzheimer's disease, with increasing emphasis on open-source tool development. His work has evolved from studying addiction-related memory ensembles during his PhD to investigating circuit dysfunction in neurological disorders, with recent publications highlighting sophisticated approaches to understanding and manipulating neural synchronization in disease models.

• 2020 Shah Research Scholar Friedman Brain Institute
• 2018 CURE Taking Flight Award from CURE Epilepsy
• 2018 AES Junior Investigator Award from American Epilepsy Society
• 2018 Nash Family Scholar from Friedman Brain Institute
• 2016 AES Young Investigator Award from American Epilepsy Society
• 2015 AES Grass Young Investigator Award
• 2014 Epilepsy Foundation Postdoctoral Fellowship

Dr. Shuman mentors a diverse research team including postdoctoral fellows, graduate students, and research associates. His lab has developed several open-source neuroscience tools including Miniscope.org platform for miniature microscope development and PhaSER for real-time phase estimation and manipulation. The lab actively shares its technological innovations with the broader neuroscience community through GitHub (https://github.com/ShumanLab) and emphasizes collaborative, rigorous science with translational potential for improving treatments for neurological disorders.