Tobias Janowitz

Roles & Affiliations: Tobias Janowitz is an Associate Professor and Co-Leader of the Cancer Center Program at Cold Spring Harbor Laboratory (CSHL). He also holds an adjunct position at the Feinstein Institute for Medical Research. His academic journey includes a M.D./Ph.D. from the University of Cambridge (2007) and prior clinical roles as an Honorary Medical Oncologist at Northwell Health and Consultant Medical Oncologist at Addenbrooke’s Hospital.

Research Focus: Janowitz’s lab investigates how tumors interact with host physiology, particularly metabolism, endocrinology, and immunology. Key areas include cancer cachexia mechanisms, tumor-induced metabolic stress, and systemic immune suppression. Recent work highlights IL-6-driven reductions in hepatic ketogenesis and glucocorticoid-mediated immunity suppression in pancreatic cancer models.

Key Findings & Trends: His publications emphasize the systemic nature of cancer, advocating for treatments targeting host-tumor interactions. Recent articles explore neuroimmune circuits in cachexia, hepatic gluconeogenesis pathways, and the role of autophagy in appetite preservation. His work bridges clinical and mechanistic insights, with implications for combination therapies.

Awards & Recognition:

• Cancer Research UK Clinician Scientist Award
• Wellcome Trust Translational Medicine Academic Clinical Lectureship
• Elected Member, American Society for Clinical Investigation (2025)

Advising & Grants: Mentored students like Rohini Guin (M.D.-Ph.D., 2025) and contributed to clinical trials on cancer immunotherapy. His research is supported by grants focusing on cachexia biology, biomarkers, and equitable healthcare access.

Labs & Teams: Leads the Janowitz Lab at CSHL, collaborating internationally on projects at the intersection of metabolism, immunity, and cancer. Active in initiatives like the NIH Biomarkers for Cachexia Workgroup.