معرفی
Tito Calì is a Full Professor in the Department of Biomedical Sciences at the University of Padova, where he has held academic positions since 2009 including Assistant Professor (RTDB) and Senior Research Associate. His research focuses on molecular mechanisms of neurodegenerative disorders, particularly cerebellar ataxia and Parkinson's disease, with emphasis on calcium signaling pathways and mitochondrial dysfunction.
His educational background includes a PhD in Biochemistry/Molecular Biology earned summa cum laude from the University of Bern and Institute for Research in Biomedicine (2008), and a Doctor in Biological Sciences with highest honors (110/110 cum laude) from the University of L'Aquila and Centre d'Immunologie Marseille Luminy (2005).
Professor Calì's research program centers on Molecular and Cellular Neuroscience, investigating how mutations in calcium-handling proteins like PMCA3 lead to cerebellar ataxia, and how proteins such as DJ-1, parkin, and alpha-synuclein regulate mitochondrial function in Parkinson's disease. His work employs advanced techniques including split-GFP probes to visualize protein dynamics and examines ER-mitochondria crosstalk critical for cellular bioenergetics.
Analysis of his 2012-2017 publications reveals a consistent trajectory exploring calcium dysregulation in neurodegeneration, with key contributions on PMCA3 mutations in ataxia, protective roles of parkin/DJ-1 in mitochondrial ATP synthesis, and alpha-synuclein's impact on calcium homeostasis. His work bridges basic molecular mechanisms with clinical manifestations of neurological disorders.
His research has been published in high-impact journals including PNAS, Journal of Biological Chemistry, Human Molecular Genetics, and Biochimica et Biophysica Acta, demonstrating significant contributions to understanding neurodegenerative disease pathogenesis.
Professor Calì operates within the University of Padova's Department of Biomedical Sciences, which provides access to multimodal neuroimaging facilities including high-density EEG, eye-tracking systems, and MRI/PET scanners. His work likely involves collaborative teams focused on translational neuroscience, though specific lab details aren't provided in the source text.
