معرفی
Carlo Casali is an Associate Professor in the Department of Medical-Surgical Sciences and Biotechnologies at Sapienza University of Rome's Faculty of Medicine and Pharmacy. His career spans over three decades in neurology with specialized expertise in neurogenetics, mitochondrial disorders, and hereditary ataxias. He directs the Neurogenetics Outpatient Clinic and coordinates the Neurological Diseases Course at the Latina campus.
His research focuses on molecular mechanisms of neurodegenerative disorders, particularly mitochondrial cardiomyopathies, Friedreich's ataxia, and hereditary spastic paraplegias. Casali pioneered the characterization of mitochondrial DNA mutations (A4300G, G8363A) and developed the hematopoietic stem cell transplant protocol for MNGIE. His current work integrates AI-driven gait analysis with exoskeleton rehabilitation for cerebellar ataxia.
Casali's publication portfolio includes 118 papers (h-index 20, 1140 citations), with recent work emphasizing biomarker discovery and digital phenotyping. His research is supported by Telethon Foundation grants and national projects including the SPG4 epidemiology study. He actively collaborates with Columbia University's Neurology Department, maintaining a 30-year research partnership.
As an educator, he coordinates multiple degree programs including Physiotherapy at Latina and teaches Neurology across medical and healthcare curricula. His clinical work bridges molecular diagnostics with patient-centered rehabilitation, focusing on improving functional outcomes in rare neurological disorders.
