معرفی
Titia de Lange is the Leon Hess Professor and Director of the Anderson Center for Cancer Research at Rockefeller University. She is a pioneering scientist in telomere biology, known for discovering the shelterin complex and elucidating its role in protecting chromosome ends from DNA damage pathways. Her work bridges molecular biology, genetics, and cancer research.
Research Focus: De Lange’s research centers on telomeres—the protective caps at chromosome ends—and their implications in aging and cancer. She identified key telomere-associated proteins (TRF1, TRF2) and the shelterin complex, which sequesters telomeres into t-loops to prevent erroneous DNA repair. Her studies link telomere dysfunction to genome instability and tumorigenesis.
Scientific Awards:
- Paul Marks Prize for Cancer Research (2001)
- Massachusetts General Hospital Cancer Center Prize (2008)
- AACR Clowes Memorial Award (2010)
- Vanderbilt Prize in Biomedical Science (2011)
- Vilcek Prize in Biomedical Science (2011)
- Breakthrough Prize in Life Sciences (2013)
- Canada Gairdner International Award (2014)
- Rosenstiel Award (2017)
Labs & Teams: At Rockefeller University, her lab investigates telomere dynamics, shelterin function, and mechanisms of genome maintenance. Her team’s work has redefined telomere biology by mapping the molecular architecture of chromosome ends and their role in disease.
