معرفی
Timothy Nottoli, PhD, is a Senior Research Scientist in the Department of Comparative Medicine at Yale University, and Co-Director of the Yale Genome Editing Center (YGEC). He holds a PhD from the University of California, Berkeley (1992) and a BA from the University of California, Santa Barbara (1985). His research focuses on genome editing, mouse models for disease mechanisms, and genetic regulation in developmental and evolutionary contexts. Dr. Nottoli collaborates extensively with investigators like James Noonan and Shuichi Ahsan, advancing studies in gene therapy, cardiovascular malformations, and genetic disorders such as systemic lupus erythematosus and microvillus inclusion disease. His work integrates CRISPR-based tools to engineer precise genetic modifications in mice, enabling disease modeling and therapeutic testing. Key projects include enhancing AsCas12a knock-in efficiency for immunogenetics studies and exploring evolutionary innovations in regulatory elements linked to developmental genes. His lab’s contributions span molecular biology, epigenetics, and translational medicine, with implications for personalized therapies and understanding genetic pathways.
Dr. Nottoli’s academic roles include co-directing the YGEC, fostering interdisciplinary genome-editing initiatives. He has authored over 30 peer-reviewed publications, addressing topics like DNA repair mechanisms, hypertension pathophysiology, and genomic instability. His research emphasizes translational applications, such as developing mouse models to study human diseases and testing pharmacological interventions (e.g., isradipine for aldosteronism). Collaborative networks extend to departments like Neurosurgery and Genetics, reflecting his commitment to team science. Professional activities include advising on genomic tools and mentoring researchers in gene-editing techniques.
His lab, part of the Yale School of Medicine, is located at the Anlyan Center. Contact details include an academic office phone (203.737.4325) and email for collaborations. No formal awards are listed, though his impactful contributions to genome editing are recognized through his publications and institutional roles.
