Tiago Fleming Outeiro

Tiago Fleming Outeiro leads the Experimental Neurodegeneration research group focusing on molecular mechanisms of neurodegenerative diseases. His work bridges fundamental research and clinical applications through close collaboration with medical professionals.

Research interests include:

• Protein misfolding and aggregation pathways
• Neurodegenerative disease mechanisms (Parkinson's, Alzheimer's, Huntington's)
• Translational drug discovery approaches
• Conserved protein homeostasis mechanisms across biological models

Outeiro employs diverse model systems from budding yeast to mammalian models to investigate disease origins. His research strategy leverages evolutionary conservation of protein quality control systems to identify therapeutic targets. The group actively works to accelerate translation of basic findings into clinical applications that improve patient outcomes.

His laboratory utilizes:

• Yeast models for high-throughput screening
• Mammalian cell cultures for mechanistic studies
• Mouse models for preclinical validation