معرفی
Dr. Thuy Tran is an Assistant Professor of Medicine (Medical Oncology) at Yale School of Medicine, specializing in melanoma and advanced skin cancers. She cares for patients at Smilow Cancer Hospital and leads translational research on melanoma brain metastases and immune therapy resistance. Her work focuses on overcoming treatment resistance and improving patient outcomes through novel drug combinations and biomarker discovery.
Education & Training:
- MD and PhD from Vanderbilt University School of Medicine (2013 and 2011)
- Internal Medicine Residency at Yale-New Haven Hospital (2015)
- Hematology/Oncology Fellowship at Yale-New Haven Hospital (2019)
- Bachelor's in Biology and French from Emory University (2005)
Research Interests:
Dr. Tran investigates mechanisms of immune resistance in melanoma, particularly targeting the MIF/CD74 axis and blood-brain barrier challenges. Her studies address complications of brain metastases and radiation necrosis, aiming to improve therapies and patient quality of life. Key areas include macrophage migration inhibitor factor (MIF) signaling, tumor microenvironment modulation, and clinical trial development for combination therapies.
Clinical Trials:
She leads multiple trials, including a Phase II study combining pembrolizumab and bevacizumab for melanoma brain metastases. Her work also evaluates novel agents like mRNA-4157 (personalized neoantigen vaccine) in adjuvant settings.
Funding & Awards:
Funded by the Yale Cancer Center T32, Calabresi K12 Immuno-Oncology Program, and Skin Cancer SPORE. No named awards explicitly listed, but her grants support clinical and translational research.
Advising & Grants:
Dr. Tran oversees clinical trials and collaborates with teams on grants exploring immune therapy combinations and biomarkers. She advises trainees in oncology and translational research.
Labs & Teams:
Associated with the Skin Cancer SPORE program and collaborates with the Janeway Society for physician-scientist development. Active in interdisciplinary teams at the Yale Cancer Center.