Thomas Kodadek

Thomas Kodadek is a Professor in the Chemistry Department at the University of Florida, where he leads the SR-CHEM-KODADEK LAB. His research spans chemical biology with a strong emphasis on translational applications, bridging the gap between basic science and clinical applications.

Dr. Kodadek's research interests focus on developing novel chemical biology approaches to tackle challenging biological problems. His work primarily centers on:

• Developing strategies to target the "undruggable" proteome through DNA-encoded libraries of non-peptidic macrocycles
• Creating innovative screening techniques for molecules with novel functions
• Using chemical tools to monitor and manipulate the immune system
• Discovering early diagnostic tests for cancers, autoimmune diseases, and neurodegenerative conditions
• Identifying compounds that act as "antigen surrogates" for therapeutic applications

Analysis of Dr. Kodadek's recent publications (2021-2025) reveals a strong focus on DNA-encoded libraries, macrocycle synthesis, and proteome targeting strategies. His work shows a progression from fundamental chemical biology techniques toward increasingly translational applications, particularly in the areas of protein degradation technologies (PROTACs), immune system manipulation, and diagnostic development. The research demonstrates interdisciplinary integration of organic chemistry, molecular biology, and immunology to address challenging problems in drug discovery.

Dr. Kodadek has received numerous prestigious awards and recognitions throughout his career:

• Makineni Award (2017) from the American Peptide Society
• Cope Scholar Award (2016) from the American Chemical Society
• Chemical Biology Faculty Member of the Year (2007)
• Faculty of 1000 Pioneer Award (2006)
• NIH Elected Fellow (1999)
• American Association for the Advancement of Science Junior Faculty Research Award (1991)
• American Cancer Society Post-doctoral Fellowship (1985)

As an entrepreneur and innovator, Dr. Kodadek has co-founded multiple biotechnology companies including Triana Biosciences (2022) and Deluge Biotechnologies (2017), demonstrating his commitment to translating basic research into practical applications. His lab has secured substantial grant funding to support their innovative research programs focused on chemical biology and translational medicine.

The Kodadek Laboratory operates at the intersection of chemistry and biology, with research teams working on multiple fronts including DNA-encoded library development, macrocycle synthesis, immune system monitoring tools, and diagnostic test development. The lab environment fosters interdisciplinary collaboration between chemists, biologists, and clinicians to address complex challenges in drug discovery and diagnostics.