جستجوی استاد راهنمای دانشگاهی

Dr. Michael Baym is an Associate Professor of Biomedical Informatics at Harvard Medical School with affiliate appointments in Microbiology and the Laboratory of Systems Pharmacology, and as an Associate Member of the Broad Institute. He leads the Baym Lab, which studies microbial evolutionary genomics and antibiotic resistance through a hybrid of experimental, computational, and theoretical approaches. His research focuses on: Antibiotic Resistance Evolution and practical interventions Mobile Genetic Elements (plasmids, phages, transposons) Computational Genomic Algorithms for big data analysis Synthetic Biology tools and technologies Key recent publications explore phage discovery systems , phylogenetic compression of microbial genomes, and RNA-guided gene drives in plasmids. His work is supported by multiple NIH/NIGMS and NSF grants including a MIRA award. Scientific honors include: Packard Fellowship (2018) Pew Biomedical Scholarship (2020) Sloan Research Fellowship (2020) A. Clifford Barger Excellence in Mentoring Award (2021) SSQBio Mentorship Award (2022) The lab actively trains PhD students and postdoctoral fellows with alumni occupying academic and industry positions globally. Current team members include researchers from interdisciplinary backgrounds working at the intersection of experiment, computation, and theory .

• Microbial Evolutionary Genomics
• Antibiotic Resistance
• Computational Biology
• +۷ مورد دیگر

Raphael Franzini serves as Associate Professor of Medicinal Chemistry at the University of Utah, actively contributing to the Biological Chemistry PhD Program. His research pioneers innovative chemical approaches for therapeutic development, with dual focus on DNA-encoded library technologies and bioorthogonal drug delivery systems. His educational foundation includes an M.S. from the Swiss Federal Institute of Technology (Lausanne) and a Ph.D. from Stanford University. This training underpins his group's multidisciplinary methodology combining organic synthesis, bioconjugation, computational modeling, and advanced imaging techniques. Dr. Franzini's research program centers on two transformative areas: First, advancing DNA-encoded library screening through computational integration to identify leads for challenging targets like Tankyrase and Sirtuin 6, with recent work addressing false negatives in machine learning prediction. Second, developing novel bioorthogonal release chemistry using isonitrile-tetrazine reactions for spatiotemporally controlled drug activation, validated in zebrafish models. His group emphasizes both technological innovation and therapeutic translation, with chemistry designed to minimize off-target effects in solid tumors. Analysis of his 15 most recent publications reveals escalating integration of computational methods with experimental library screening, alongside refinement of bioorthogonal release kinetics. The work spans chemical biology, medicinal chemistry, and pharmaceutical sciences, with growing emphasis on machine learning for library data interpretation and in vivo validation of drug-release systems. Dr. Franzini maintains an active research laboratory that provides comprehensive training in cutting-edge drug discovery methodologies. His group culture prioritizes both scientific innovation and researcher development, with projects spanning from fundamental reaction kinetics to therapeutic applications. The lab's infrastructure supports organic synthesis, molecular imaging, and computational analysis for advancing precision therapeutics.

• Drug Discovery
• Medicinal Chemistry
• Bioorthogonal Chemistry
• +۳ مورد دیگر

Joshua J. Coon is a Professor at the University of Wisconsin-Madison with appointments in the Department of Biomolecular Chemistry and the Department of Chemistry. He leads the Coon Group, focusing on advancing mass spectrometry technologies for proteomics, metabolomics, and lipidomics. His research addresses fundamental questions in cell biology, including stem cell differentiation, epigenetic regulation, and cancer biomarker discovery. Affiliations : Director of the NIGMS National Center for Quantitative Biology of Complex Systems. Research Emphasis : Instrumentation development, data analysis software, ion chemistry, and biological applications of proteomics. Laboratory : Located in the Genome Center of Wisconsin with a dozen hybrid mass spectrometers, including Orbitrap systems. Collaborations : Long-term partnership with Thermo Fisher Scientific and the Wisconsin Alumni Research Foundation (WARF) for technology commercialization. Training : Mentored 27 Ph.D. students since 2009, emphasizing interdisciplinary research and professional development.

• Bioanalytical Chemistry
• Mass Spectrometry
• Proteomics
• +۴ مورد دیگر

Dr. Seung-gu Lee is a Principal Scientist and Director of the Synthetic Biology Institute at the Korea Research Institute of Bioscience and Biotechnology (KRIBB). He holds a Ph.D. in Biotechnology from KAIST and serves as the President of the Korean Society of Enzyme Engineering. His leadership extends to multiple national research initiatives focused on advancing synthetic biology infrastructure and applications. Dr. Lee is a leading expert in genetic circuits and enzyme engineering for synthetic biology. He pioneered the development of GESS (Genic Enzyme Screening System/Circuits) technology, which enables ultra-high-speed screening of trace enzyme activities at the single-cell level. His research focuses on applying intelligent genetic circuits to biosensors, metabolic control, and bioprocess development. He is actively integrating AI-based automated workflows with synthetic biology to revolutionize the speed and scale of biological research. His work spans multiple disciplines including enzyme engineering, genetic circuit design, metabolic engineering, and biofoundry development. Dr. Lee currently leads several major research initiatives including the Korea-North America Biofoundry Collaboration Global Joint Research Center, the development of core technologies for advanced synthetic biology, and the establishment of biofoundry infrastructure. His research team at KRIBB works at the intersection of synthetic biology, enzyme engineering, and AI-based automation to develop next-generation bio-manufacturing platforms. The lab has made significant contributions to genetic circuit design, biosensor development, and plastic biodegradation technologies.

• Synthetic Biology
• Enzyme Engineering
• Genetic Circuits
• +۳ مورد دیگر

Professor Luke Lairson leads the Lairson Laboratory at The Scripps Research Institute (TSRI), focusing on chemical biology to study cell fate mechanisms in disease. His work spans small molecule discovery targeting cancer stem cells, tumor microenvironment modulation, and myelination enhancement using primary human and rodent cell models. Education: PhD in Chemistry (2007, University of British Columbia), BS in Biochemistry (2002, University of Guelph). Professional roles include Assistant Professor at TSRI (2010–present), Principal Investigator at the Genomics Institute of the Novartis Research Foundation (2010–2011), and Director of High Throughput Discovery at California Institute for Biomedical Research (2016–2017). Research Interests: Chemical approaches to cancer immunotherapy, drug discovery for neurodegenerative diseases, and modulation of immune checkpoint proteins. Key projects include STING agonist development, HSP90 inhibitors, and metabolite-driven oligodendrocyte maturation. Publications: Over 50 peer-reviewed articles, including high-impact work in PNAS , Nature Chemical Biology , and Cancer Research . Recent focus areas include microbiota-derived STING activators and JAK-inhibitor immunotherapy combinations. Awards: Canadian Society for Chemistry Boehringer Ingelheim Thesis Award (2010), Royal Society Short Visit Award (2007), and multiple scholarships for organic chemistry innovation. Lab Activities: Integrates high-content screening, medicinal chemistry, and proteomics to identify mechanism-based therapies. Current initiatives include repurposing drugs for remyelination and developing non-nucleotide STING agonists for systemic cancer immunotherapy.

• Chemical Biology
• Drug Discovery
• Cancer Biology
• +۴ مورد دیگر

Peter Verwilst is an Associate Professor at the Medicinal Chemistry division of the Rega Institute for Medical Research , part of KU Leuven 's Department of Pharmaceutical and Pharmacological Sciences. He leads projects in allosteric modulation of enzyme targets , fluorescent markers for neurodegenerative diseases , and novel antimicrobial development , particularly focusing on Gram-negative bacteria and HIV-related therapies. His research integrates computational modeling , chemical synthesis , and fluorescent probe design . He supervises PhD students including Margaux Billen , Eline Goffin , and Radu Bulai , and collaborates with institutions like Masaryk University and the Institut Pasteur de Lille. Current projects explore CCR5 signaling modulators , PurK inhibitors , and DNA-Encoded Libraries for P. aeruginosa antibiotics. Scientific awards include supporting students like Radu Bulai in obtaining FWO PhD Fellowships . His teaching includes Organische chemie I & II and Medicinale chemie courses. The lab recently celebrated securing a C1 grant and welcomes international collaborations.

• Medicinal Chemistry
• Allosteric Modulation of Enzyme Targets
• Fluorescent Markers for Neurodegenerative Diseases
• +۵ مورد دیگر

Murugesan Palaniappan is an Assistant Professor in the Department of Pathology & Immunology at Baylor College of Medicine, and Group Leader in the Center for Drug Discovery. He also serves as a Member of the Dan L Duncan Comprehensive Cancer Center. His research focuses on drug discovery methodologies, particularly using DNA-encoded chemical libraries, and addresses challenges in breast cancer therapy and endocrine-resistant diseases. Dr. Palaniappan holds a PhD from the University of Madras, India (2007), and completed postdoctoral training at the University of Michigan (2011). His professional interests span breast cancer therapeutics, estrogen receptor signaling, and innovative drug development strategies. His research emphasizes the design of novel inhibitors targeting estrogen receptor mutants, leveraging DNA-encoded libraries for high-throughput screening. Key areas include overcoming endocrine resistance in metastatic breast cancer, developing male contraception via kinase inhibition, and combating antibiotic resistance through enzyme inhibitor discovery. His work bridges chemical biology, molecular endocrinology, and translational oncology. Dr. Palaniappan has secured grants including $769,179 from CPRIT (2022-2025) for next-generation estrogen receptor inhibitors and $160,000 from NIH/NCI (2021-2023) for precision drugs targeting Y537S mutant ER. He collaborates with interdisciplinary teams in the Center for Drug Discovery and contributes to initiatives in the Dan L Duncan Cancer Center. His lab integrates synthetic chemistry, molecular biology, and computational approaches to advance drug discovery pipelines.

• Drug Discovery and Development
• Breast Cancer Therapeutics
• DNA Encoded Chemical Library Screening
• +۴ مورد دیگر

Prof. Dr. Karl-Josef Dietz holds a Professorial Chair (C4) in Biochemistry and Physiology of Plants at the Faculty of Biology, Bielefeld University since 1997. He is Head of the working group 'Biochemistry and Physiology of Plants' at the Center for Biotechnology (CeBiTec). His academic career spans prestigious institutions including Julius-Maximilians-Universität Würzburg (where he completed his PhD and Habilitation), Harvard University (postdoc position), and numerous international research stays in France, Japan, and the USA. Prof. Dietz's research focuses on plant stress responses, redox regulation, and photosynthesis. His work explores how plants acclimate to multiple environmental stresses through molecular signal integration, with particular emphasis on reactive oxygen species (ROS) signaling, thiol peroxidases, and oxylipin pathways. His laboratory investigates the mechanisms of redox regulation in chloroplasts and mitochondria, stress sensing, and plant defense responses against pathogens and abiotic challenges. His recent publications reveal a strong focus on redox biology, stress acclimatization mechanisms, and the role of peroxiredoxins in plant stress responses. His work spans both fundamental biochemical investigations and applied research in plant protection and stress tolerance. Scientific Awards and Recognition: Science Prize of the University Foundation Würzburg (1985) Gay-Lussac-Humboldt Prize (2012) Prof. Dietz has served in numerous leadership roles including Dean of the Faculty of Biology (2004-2006), President of the German Botanical Society (2012), and as a member of the Science Board of the German Research Foundation (DFG). He serves on the editorial boards of several prestigious journals including Journal of Experimental Botany, Physiologia Plantarum, and Plant Physiology. His professional activities demonstrate extensive involvement in national and international scientific communities, including the German Society of Botany, the American Society of Plant Biologists, and the Federation of European Societies of Plant Biology.

• Plant Physiology
• Biochemistry
• Redox Regulation
• +۵ مورد دیگر

Dr. Fabian Barthels is a Researcher and Research Group Leader at the Institute of Pharmaceutical and Biomedical Sciences of Johannes Gutenberg-Universität Mainz , Germany. His work focuses on RNA methyltransferases, epitranscriptomics, and medicinal chemistry technologies. Ph.D. in Medicinal Chemistry (University of Mainz, 2018) Biochemistry M.Sc. (University of Tübingen, 2016) Biochemistry B.Sc. (University of Tübingen, 2013–2016) Dr. Barthels' research explores dysregulation of RNA modifications in disease pathology, developing selective covalent/non-covalent inhibitors for RNA methyltransferases using DNA-encoded libraries and PROTACs. His group created microscale thermophoresis assays and 3D-printed lab equipment like FINDUS and a differential scanning fluorometer. His group's publications highlight advancements in RNA-MST protocols, METTL1/DNMT2 inhibitor discovery, and photoaffinity probes for viral proteases. Recent work includes fluorescent MTase probes (Angewandte Chemie 2024) and RNA-ligand interaction studies (Chemical Science 2023). 2023 Boehringer-Ingelheim Foundation Dissertation Award 2022 Walter-Schunack Prize in Medicinal Chemistry 2022 Phoenix Pharmacy Award (co-awarded) 2016–2018 Deutschlandstipendium for academic potential Dr. Barthels' lab includes researchers like Ariane Frey (Poster Award winner) and Annabelle Weldert (best presentation awardee). His DFG-funded Transregio 319 project on RNA Modification and Processing and CZS MAINCE initiative on Medical AI demonstrate his grant leadership.

• RNA Biology
• Medicinal Chemistry
• Epitranscriptomics
• +۶ مورد دیگر

Jory Lietard is an Assistant Professor in the Department of Inorganic Chemistry at the Faculty of Chemistry. His research focuses on nucleic acid chemistry, RNA/DNA microarray synthesis, and light-directed chemical synthesis. He leads three major research projects: FANArrays (2022–2025), RNA arrays: die nächste Generation, and Large libraries of base-modified RNA for Nanopore sequencing (2021–2024). His work contributes to UN Sustainable Development Goals related to sustainable innovation in biosensors and biotechnology. Education: PhD (Privatdozent title) Key Projects: FANArrays: High-throughput platform for nucleic acid synthesis (2022–2025) RNA arrays: Next-generation RNA microarray development Base-modified RNA libraries for nanopore sequencing (2021–2024) Research interests include nucleic acid photolithography, biosensor design, and enzymatic synthesis of oligonucleotides. Recent advancements include color-corrected optical systems for high-resolution nucleic acid printing and accelerated RNA microarray synthesis. Collaborations span material science, optics, and synthetic biology. Media contributions include expert commentary on RNA chip innovations and DNA-based art (e.g., 16 million color palette creation). He actively engages in scientific presentations, including posters at international conferences on photolithography and enzymatic synthesis.

• Nucleic Acid Chemistry
• RNA Microarray Synthesis
• DNA Photolithography
• +۳ مورد دیگر

Michael Pollastri serves as Senior Vice Provost and Academic Lead of the Roux Institute at Northeastern University, overseeing academic and research initiatives. He joined Northeastern's Department of Chemistry and Chemical Biology in 2009, became department chair in 2015, attained full professorship in 2017, and served as interim dean of the College of Science from March 2019. His academic journey began with a master's degree from Duke University, followed by a doctorate developed through a unique partnership between Pfizer and Brown University's Department of Chemistry. Duke University: Master's degree Brown University/Pfizer: Doctorate Pollastri's research centers on medicinal chemistry and drug discovery for neglected tropical diseases , with emphasis on human African trypanosomiasis, Chagas disease, and leishmaniasis. His work pioneers kinase inhibitor repurposing , multiparameter compound optimization , and structure-activity relationship studies to develop novel antiparasitic therapeutics. He integrates high-throughput screening with lead optimization strategies to address critical unmet medical needs in resource-limited settings. Analysis of his recent publications (2021-2025) reveals consistent focus on optimizing quinazolines, azaindoles, and carbazole derivatives against kinetoplastid parasites. His work demonstrates systematic progression from hit identification to lead optimization, with particular attention to physicochemical properties, target specificity, and broad-spectrum activity against trypanosomatid pathogens. During his tenure at Boston University (2007-2009), Pollastri established the Center for Molecular Discovery—a collaborative resource integrating high-throughput screening and medicinal chemistry capabilities. This initiative exemplifies his commitment to building infrastructure for antiparasitic drug discovery through academic-industry partnerships.

• Neglected Tropical Diseases
• Drug Discovery
• Medicinal Chemistry
• +۳ مورد دیگر

Albert Keung is an Associate Professor in the Department of Chemical and Biomolecular Engineering at North Carolina State University, holding titles of University Faculty Scholar and Goodnight Distinguished Scholar. His research integrates engineering, biology, and physics to develop molecular technologies for understanding and manipulating chromatin dynamics. Key focuses include synthetic biology platforms for epigenetic control, stem cell engineering for neuroepigenetic disorders, and DNA-based information storage systems. His lab develops tools to study chromatin biochemistry and 3D structure, enabling insights into disease mechanisms and applications like antibody production and cancer therapies. Notable achievements include the 2023 Langer Prize for innovations in DNA data storage and pioneering work on epigenetic editing systems. The Keung Lab also explores neuroepigenetic models using human cerebral organoids and synthetic biology approaches to decode gene regulation. Research interests span from foundational epigenetic mechanisms to applied technologies, with over 50 peer-reviewed articles. His work bridges fundamental science and translational applications, addressing challenges in biotechnology, medicine, and data storage. Current projects emphasize scalable DNA storage systems, synthetic epigenetic circuits, and mechanistic studies of UBE3A-related disorders. Academic contributions include an NSF CAREER Award (2022) and leadership in the Synthetic Biology community. The lab collaborates across disciplines, leveraging engineering principles to solve complex biological problems. Education and training initiatives emphasize training the next generation of bioengineers through interdisciplinary research programs.

• Synthetic Biology
• Neural Engineering
• Stem Cell Engineering
• +۳ مورد دیگر

Jennifer Schomaker serves as the Edward and Nancy Fody Professor of Chemistry at the University of Wisconsin–Madison. Her research focuses on developing innovative catalytic methods for transforming simple hydrocarbons into complex synthetic building blocks, with emphasis on utilizing greenhouse gases like CO 2 and N 2 O. Her group explores reaction mechanism elucidation, catalyst design, and applications in natural product synthesis. Key research areas include: Multicomponent Reactions: Installing multiple carbon-heteroatom bonds in a single step, particularly through aziridination of allenes. Green Catalysis: Activating CO 2 and N 2 O for sustainable chemical transformations. Strained Ring Systems: Synthesis of 1,4-diazaspiropentane (DASP) for protein profiling and biomedical applications. Total Synthesis: Strategic synthesis of bioactive natural products to advance pharmaceutical and materials science. Her recent publications highlight advancements in photoredox catalysis, iron/silver-catalyzed C-H functionalization, and mechanistic studies of nitrene transfer. The group trains students in synthetic organic chemistry, organometallic techniques, and scientific communication, with alumni securing positions in academia, industry, and top postdocs. Notable group members include: PhD Alumni: Christopher Adams (Intel), Julie Alderson (PPG), Bob (Yun) Hu (UC Berkeley), Jed Kim (2025 graduate). Master's Alumni: Ethan Licht (Hilldale award winner), Sierra Thein (2025 graduate). Undergraduates: Colin Crawford (2023), Ashley Palecek (2024).

• Organic Chemistry
• Organometallic Chemistry
• Catalysis
• +۷ مورد دیگر

Professor Mike Waring is affiliated with Newcastle University , where he contributes to advancements in DNA-encoded library synthesis and medicinal chemistry . His work focuses on optimizing chemical reactions for drug discovery applications.

• Medicinal Chemistry
• Drug Discovery
• DNA-Encoded Libraries
• +۵ مورد دیگر

Josef Järhult is a Professor at Uppsala University's Faculty of Medicine, holding dual appointments in the Department of Medical Sciences (Infectious Diseases) and as a Guest Researcher in the Department of Medical Biochemistry and Microbiology. His work spans multiple disciplines with a focus on the intersection of human, animal, and environmental health. At the Academic Hospital, he works in the Infection department (entrance 34, 1st floor), and at the university, he is based at BMC Husargatan 3 in Uppsala. Dr. Järhult's research program centers on antibiotic resistance mechanisms and transmission, particularly examining the environmental dimension of antimicrobial resistance. His work frequently employs the One Health framework, investigating connections between human medicine, veterinary science, and environmental factors. Key areas include the study of ESBL-producing bacteria in water systems, influenza virus transmission between species, and antimicrobial resistance patterns across different settings including hospitals, farms, and wildlife. His laboratory work often involves genomic analysis of resistant pathogens and examination of resistance gene transmission across human-animal-environment interfaces. Analysis of his recent publications reveals a strong emphasis on spatial and temporal patterns of antimicrobial resistance, with significant work conducted in Sweden and Southeast Asia. His research program demonstrates consistent productivity with publications spanning clinical infectious diseases, environmental microbiology, and translational research connecting laboratory findings to public health implications. The work often involves international collaborations across Europe, Southeast Asia, and North America. Dr. Järhult has contributed significantly to understanding how antimicrobial resistance develops and spreads in natural environments, particularly examining the role of water systems and wildlife as reservoirs and vectors for resistant bacteria. His work on influenza viruses in waterfowl has provided important insights into viral evolution and transmission dynamics between wild birds and domestic animals.

• Antibiotic Resistance
• Influenza Virus Research
• One Health Approach
• +۳ مورد دیگر