معرفی
Dr. Fabian Barthels is a Researcher and Research Group Leader at the Institute of Pharmaceutical and Biomedical Sciences of Johannes Gutenberg-Universität Mainz, Germany. His work focuses on RNA methyltransferases, epitranscriptomics, and medicinal chemistry technologies.
- Ph.D. in Medicinal Chemistry (University of Mainz, 2018)
- Biochemistry M.Sc. (University of Tübingen, 2016)
- Biochemistry B.Sc. (University of Tübingen, 2013–2016)
Dr. Barthels' research explores dysregulation of RNA modifications in disease pathology, developing selective covalent/non-covalent inhibitors for RNA methyltransferases using DNA-encoded libraries and PROTACs. His group created microscale thermophoresis assays and 3D-printed lab equipment like FINDUS and a differential scanning fluorometer.
His group's publications highlight advancements in RNA-MST protocols, METTL1/DNMT2 inhibitor discovery, and photoaffinity probes for viral proteases. Recent work includes fluorescent MTase probes (Angewandte Chemie 2024) and RNA-ligand interaction studies (Chemical Science 2023).
- 2023 Boehringer-Ingelheim Foundation Dissertation Award
- 2022 Walter-Schunack Prize in Medicinal Chemistry
- 2022 Phoenix Pharmacy Award (co-awarded)
- 2016–2018 Deutschlandstipendium for academic potential
Dr. Barthels' lab includes researchers like Ariane Frey (Poster Award winner) and Annabelle Weldert (best presentation awardee). His DFG-funded Transregio 319 project on RNA Modification and Processing and CZS MAINCE initiative on Medical AI demonstrate his grant leadership.
