Thomas Klockgether

Prof. Dr. Thomas Klockgether is a Professor of Neurology at the University of Bonn and affiliated with the German Center for Neurodegenerative Diseases (DZNE). His research focuses on spinocerebellar ataxias (SCAs), emphasizing translational approaches to develop therapies targeting disease genes. He leads projects on MRI biomarkers, digital assessment tools (e.g., SARAhome), and patient-reported outcomes via e-health apps. His work includes longitudinal cohort studies like RISCA and ESMI, identifying early disease markers and staging models. Collaborations span neuroimaging (CerebNet AI tool), genetic studies (SPORTAX registry), and clinical trials for therapeutic intervention.

Key achievements include establishing ultra-high-field MRI protocols, validating fluid biomarkers (e.g., neurofilament light chain), and developing automated scoring methods for gait and speech. He chairs the PROFA project to assess socioeconomic impacts of ataxia and co-leads international initiatives like the ESMI staging model for SCA3. His research bridges clinical practice and basic science, prioritizing patient-centric outcomes and cross-disciplinary innovation.