Thomas Gabler

Thomas Gabler is a researcher at the Institute of Biochemistry, BOKU - University of Natural Resources and Life Sciences Vienna, Austria. His work focuses on the structural and functional analysis of enzymes involved in heme biosynthesis in prokaryotes, particularly Gram-positive bacteria like Listeria monocytogenes. Key projects include studying coproporphyrin ferrochelatase, coproheme decarboxylase, and their roles in bacterial pathogenesis and metal homeostasis.

• Research Interests: Biochemistry, structural biology, enzyme mechanisms, heme biosynthesis, bacterial metabolism, spectroscopic analysis.
• Methodology: Utilizes X-ray crystallography, resonance Raman spectroscopy, and mutagenesis to explore active site architecture and reaction dynamics.
• Collaborations: Works with international teams on projects funded by the Austrian Science Fund (FWF) and European research initiatives.
• Publications: Over 24 publications with a focus on catalytic residues, porphyrin-metal interactions, and redox-sensitive protein artifacts.