معرفی
Thomas Bourgeron is a Professor and head of the Human Genetics and Cognitive Functions Unit at the Institut Pasteur in Paris, France. His research integrates psychiatry, neuroscience, and genetics to investigate the causes of autism spectrum disorders (ASD) and improve clinical management. He leads a multidisciplinary team and numerous international research initiatives.
- Institut Pasteur, Paris
- Human Genetics and Cognitive Functions Unit
- Principal Investigator, EU-AIMS, PARIS Study, Phelan-McDermid Syndrome Project
His research focuses on identifying genetic mutations linked to ASD, particularly in synaptic genes (NLGN, SHANK, CNTN) and the melatonin pathway affecting sleep. His team employs high-throughput genomics, brain imaging (MRI, EEG), mouse models, and human iPSCs to study functional impacts and develop therapeutic strategies. He emphasizes data sharing and open science through tools like GeneTrek and GRAVITY.
His recent publications reveal genetic heterogeneity in autism, brain connectivity patterns, and phenotypic stratification using electrophysiology and behavioral analysis. His work bridges molecular mechanisms with clinical manifestations, aiming to identify common pathways for targeted interventions.
- Phenotypic effects of genetic variants in autism
- Genetic correlates of phenotypic heterogeneity
- Stratification of autistic phenotypes using EEG
- Functional impact of SHANK3 mutations
- Proteomic analysis of the pineal gland in autism
Thomas Bourgeron mentors numerous PhD students, postdoctoral researchers, and engineers. He collaborates with leading institutions and clinicians, including Professor Christopher Gillberg at the University of Gothenburg. His lab is actively recruiting in human genetics and neuroimaging.
He contributes to public education through lectures, open-access tools, and outreach initiatives like the CléPsy platform and educational videos for families of autistic children.
