معرفی
Professor Thomas A Hughes is a Professor of Biosciences at York St John University's School of Science, Technology and Health. He holds a leadership role in cancer research, with a focus on improving cancer outcomes through understanding gene expression regulation, tumor microenvironment interactions, and novel therapeutic development. His work integrates clinical collaboration with NHS professionals and interdisciplinary partnerships in nanomedicine engineering.
Research Interests:
- Regulation of gene expression in oncogenic contexts
- Tumor microenvironment dynamics and chemoresistance mechanisms
- Cancer biomarker identification and targeted therapy design
- Nanoparticle-based drug delivery systems for precision oncology
Collaborations:
- NHS clinicians (surgeons, oncologists, pathologists)
- Engineering/chemistry teams developing Foslip nanoparticles and Affimer conjugates
- Clinical translation of imaging agents for colorectal cancer surgery
Publications:
Recent work emphasizes chemoresistance pathways in triple-negative breast cancer, oxysterol signaling, and translational nanomedicine applications. Over 80 peer-reviewed articles highlight his contributions to understanding metabolic-cancer interactions and biomarker-driven therapies.
Advising/Grants:
Supervised 26 doctoral students with expertise in molecular oncology and drug development. Active in securing research grants for translational cancer projects.
