Tessa Crompton

Professor Tessa Crompton (ORCID: 0000-0002-8973-4021) is a leading researcher in experimental immunology at the University College London, affiliated with the Infection, Immunity & Inflammation Department. Her work explores how morphogens like Sonic hedgehog and BMP4 regulate T-cell development and immune function in barrier tissues.

• PhD (University College London, 1990)
• BA (University of Oxford, 1986)

Her research bridges developmental and clinical immunology, focusing on:

• Thymic epithelium signaling in T-cell maturation
• Morphogen roles in adult immune homeostasis
• Translational applications in transplantation and metabolic diseases
• Single-cell dynamics in immune pathogenesis

Key trends in her 15 most recent publications include:

• TCR repertoire analysis in pediatric multisystem inflammatory syndromes
• Hedgehog pathway modulation for allergic and transplant-related inflammation
• Comparative fetal vs adult thymus development
• Metabolic-immune crosstalk in genetic disorders

At UCL, she supervises BSc Biomedical Sciences projects and scientific writing modules, contributing to next-generation immunology education.

Her affiliations span the Great Ormond Street Institute of Child Health and University College London, with research aligned to the UN Sustainable Development Goal 3: Good Health and Well-being.