معرفی
Dr. Alexandra Kreins is a Wellcome Clinical Research Fellow and Honorary Consultant at the Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London. Her work focuses on paediatric immunology, particularly thymus biology and T-cell lymphopoiesis in the context of thymus transplantation for congenital athymia at Great Ormond Street Hospital.
Her primary research interests include Inborn errors of immunity (especially SCID and thymic stromal cell defects), T lymphocyte development and biology, thymus biology, and stem cell biology. She also investigates cellular therapies, thymus replacement treatment, and targeted biological treatments for immunodeficiency disorders. Her work aims to improve outcomes for children with congenital athymia through translational research and novel therapeutic approaches.
Analysis of Dr. Kreins' recent publications reveals a strong focus on congenital athymia and inborn errors of immunity. Her work spans from basic thymus biology and T-cell development to clinical applications, including thymus transplantation and novel antiviral treatments for immunocompromised children. Key trends include the development of diagnostic assays for T-lymphocytopenia, spatial mapping of thymus tissue, and guidelines for patient management.
Dr. Kreins has been awarded the following scientific honors:
- Wellcome Trust Career Development Fellowship
Dr. Kreins is available for supervision of research degrees and collaborative projects. She is the principal investigator of a Wellcome Trust Career Development Fellowship, which supports her research on thymus biology and T-cell lymphopoiesis in congenital athymia. She also engages in consultancy and outreach activities.
Dr. Kreins is a key member of the Thymus Transplantation Research Programme at Great Ormond Street Hospital (GOSH) and the UCL Great Ormond Street Institute of Child Health (ICH). This program is one of only two worldwide centers offering thymus transplantation for congenital athymia and focuses on identifying novel inborn errors of immunity and developing ex vivo models for disease.
