Tarik Smani Hajami

Tarik Smani Hajami is a University Professor in the Department of Medical Physiology and Biophysics at the University of Seville. He leads the Translational Research in Cardiovascular Pathophysiology group, focusing on mechanisms of calcium signaling, miRNA regulation, and cardiovascular diseases. His work spans cardiac protection, angiogenesis, and translational medicine.

Key research projects include the role of Orai channels in angiogenesis (PID2022-136279NB-C22) and fibroblast progenitor cells in heart failure (PROYEXCEL_00530). He has participated in studies on vascular smooth muscle response to hypoxia (1FD97-1614). His research integrates experimental and computational approaches, with a focus on clinical translation.

Research interests include:

• Calcium signaling in cardiovascular and skeletal muscle disorders
• MiRNA modulation in cardiac ischemia-reperfusion injury
• Role of TRP channels in cancer cell migration
• Therapeutic targets for heart failure and cardiotoxicity

Publications highlight studies in Biomedicines, Molecular Therapy, and Frontiers in Cell and Developmental Biology. He has directed PhD theses on vascular tone mechanisms (Ávila Medina, 2017) and cardioprotection against ischemia (Diaz Carrasco, 2016).

His lab collaborates on projects involving microRNA biomarkers for coronary restenosis and cardiac remodeling. Virtual reality applications for surgical improvements and miRNA-driven therapeutic strategies are key translational focuses.