معرفی
Tarek Fahmy serves as Associate Professor of Biomedical Engineering at Yale University's School of Engineering with additional appointments in Immunobiology. His research focuses on biomaterials-driven immunotherapy and immunodiagnostics, directing the Fahmy Laboratory in Yale's Malone Engineering Center. The lab develops nano- and micro-scale systems for artificial antigen presentation, vaccine delivery, and non-invasive immune monitoring, with applications in cancer immunotherapy and autoimmune disease treatment.
- Ph.D., The Johns Hopkins University
Dr. Fahmy pioneers biomimetic material design to modulate immune responses through four core approaches: artificial antigen-presenting cell platforms using biodegradable polymers for T cell stimulation; modular nanoparticle vaccines enabling rapid pathogen response; label-free electronic sensors for real-time immune monitoring; and MRI-based cellular tracking of immune cells. His work integrates polymer chemistry, nanotechnology, and immunology to create adaptable systems for targeted drug delivery—particularly in lupus treatment—and cancer immunotherapy, emphasizing FDA-approved biocompatible materials for clinical translation.
Analysis of his publication record reveals consistent innovation in nanomaterial applications for immune modulation. Key trends include development of pH-responsive dendrimers for dual drug delivery/imaging, carbon nanotube-based platforms for enhanced lymphocyte activation, and nanowire sensors enabling label-free T cell response detection. His research demonstrates increasing focus on translational applications, with recent work targeting autoimmune T cells in lupus and developing modular vaccine systems against emerging pathogens.
- Early Career Award from the Coulter Foundation (2006) for "Multimodal Nanoparticles for Targeting Autoimmune T Cells in Systemic Lupus Erythematosus"
- Ranked among top five translational junior faculty by Bioentrepreneur (Nature Biotechnology) in 2013
Dr. Fahmy leads a multidisciplinary team supported by National Institutes of Health (NIH), National Science Foundation (NSF), Yale Institute of Nanoscale and Quantum Engineering, and Wallace Coulter Foundation grants. His lab maintains active collaborations with Yale School of Medicine clinicians including Dr. Joseph Craft (Rheumatology Chief) and imaging specialists, focusing on translating nanoparticle technologies from bench to bedside. Current projects emphasize clinical applications for autoimmune disease diagnosis and targeted therapy.
The Fahmy Laboratory occupies 1,700 sq. ft. in Yale's Malone Engineering Center, featuring polymer formulation facilities, biosafety level 2+ tissue culture suites, cell analysis equipment, and animal study infrastructure. The lab shares Yale School of Medicine resources including 4T/8T/11T MRI scanners and Yale Bioimage Suite® for advanced imaging analysis, enabling integrated research from materials synthesis to in vivo validation.