معرفی
Mark N. Lee serves as an Assistant Professor of Laboratory Medicine at Yale School of Medicine with secondary appointments in Pathology. He is an active member of Yale's Human and Translational Immunology (HTI) Program and the Cancer Immunology Research Program at Yale Cancer Center.
- B.S. and M.S. in Molecular Biophysics & Biochemistry from Yale University (2004)
- M.D. and Ph.D. in Immunology from Harvard Medical School (2013, 2015)
- Residency in Clinical Pathology at Brigham and Women's Hospital
- Fellowship in Transfusion Medicine through Harvard Joint Program
- Postdoctoral fellowship at Dana-Farber Cancer Institute
Dr. Lee's research focuses on adaptive immunity mechanisms, particularly T-cell receptor specificity, antigen presentation, and immune evasion in cancer. His work bridges genomic analysis of immune responses with clinical applications in hematologic malignancies and autoimmune disorders. He employs cutting-edge approaches including pathogen-sensing response mapping and interferon transcriptional network analysis to develop novel immunotherapies targeting tumor microenvironments.
His publication record demonstrates consistent contributions to understanding genetic regulation of immune phenotypes, with emphasis on HLA-restricted T-cell responses, ERAP2 transcript regulation during viral infection, and STAT3 mutations in hematologic disorders. These works collectively advance precision immunology approaches for cancer and autoimmune diseases.
- AABB Foundation Scientific Research Grant Award (2022)
As a physician-scientist, Dr. Lee maintains active clinical service in transfusion medicine while leading his research laboratory. His work has received support from major foundations including the AABB Foundation. He collaborates extensively with immunologists and oncologists across Yale, particularly with Dr. David Hafler's group in autoimmune research. His training background uniquely positions him at the intersection of laboratory medicine, immunology, and translational cancer research.
Dr. Lee leads the Lee Lab at Yale, which investigates molecular mechanisms of immune recognition with applications in cancer immunotherapy and autoimmune disease treatment. The lab utilizes advanced genomic and proteomic approaches to study antigen presentation pathways and immune checkpoint regulation.
