معرفی
Dr. Mark Mamula is a Professor of Medicine (Rheumatology) at Yale School of Medicine, part of Yale University. He focuses on autoimmune disease mechanisms, particularly in systemic lupus erythematosus (SLE) and type 1 diabetes. His research explores how post-translational protein modifications disrupt immune tolerance, leading to autoimmunity. Notably, his lab identified key roles for B cells in antigen presentation and epitope spreading in lupus. Dr. Mamula is also investigating therapeutic applications of these findings, including anti-tumor vaccines in breast and colon cancers.
Education: PhD (University of Oklahoma, 1986), MS (University of Notre Dame, 1982), BA (University of California, Los Angeles, 1979).
Research Interests: Autoantigen processing, T cell signaling, protein isoaspartyl modifications, β-cell stress in diabetes, and cancer immunology.
Publications reflect a focus on molecular mechanisms in autoimmunity and translational medicine, with recent work on biomarkers (e.g., PDIA1 in diabetes) and therapeutic inhibitors targeting antigen presentation pathways. His phased retirement status suggests continued research engagement.
Labs/Teams: Laboratory of Autoimmunity and Immunology at Yale School of Medicine, collaborating with cancer immunology and diabetes research groups.
