معرفی
Dr. Susan K. Murphy is a tenured Associate Professor in Duke University's Department of Obstetrics and Gynecology, where she serves as Chief of the Division of Reproductive Sciences. She holds secondary appointments in the Department of Pathology and the Nicholas School of the Environment. As a molecular biologist specializing in epigenetics, her research examines how environmental exposures influence disease development across generations.
Her primary investigations include:
- Epigenetic mechanisms in ovarian cancer recurrence and chemoresistance
- Preconception impacts of environmental toxins (e.g., cannabis) on sperm epigenetics
- Developmental Origins of Health and Disease (DOHaD) through the Newborn Epigenetics STudy (NEST) cohort
Recent publications (2025) demonstrate strong focus on environmental epigenetics, spanning prenatal exposures, pollution effects, and epigenetic biomarkers in gynecologic oncology. Research consistently integrates molecular biology with population health approaches.
Active grants support her work on:
- Paternal toxic exposures and autism risk (DoD)
- Ninjurin 1's role in ovarian cancer ferroptosis (DoD)
- Genomic imprinting in NAFLD (NIDDK)
- Postdoctoral training in neurodevelopmental conditions (NIMH/NIH)
She directs the Murphy Lab and co-founded the NEST cohort, maintaining long-term follow-up studies on prenatal exposures. Collaborations include the NICHES Children's Environmental Health Center and CIPHERS Project.
