معرفی
Larry Feig is a Professor in the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. His research focuses on molecular mechanisms underlying sex-dependent effects of stress across generations, particularly involving Ras-GRF1 and epigenetic inheritance via sperm miRNAs. He holds a PhD from Harvard University and has held faculty positions since 1987. He teaches courses in molecular biology and signal transduction, and has been awarded the Distinguished Faculty Award (2017).
Education:
- PhD in Biological Sciences, Harvard University (1982)
- MS in Chemistry, Massachusetts Institute of Technology (1976)
- BS in Chemistry, Columbia University (1974)
Research Interests:
Feig's lab investigates:
- Sex-specific stress responses in adolescents
- Transgenerational epigenetic inheritance via sperm miRNAs
- Lamarckian inheritance mechanisms in mammals
- Neuroendocrine regulation of HPA axis
Publications Trends:
Recent work emphasizes miRNA-mediated transgenerational effects of paternal stress exposure. Key themes include:
- Role of miR-34c/449 in stress transmission
- Epigenetic mechanisms in multi-generational behavior
- Interactions between astrocytes and sperm biology
- Neurodevelopmental impacts of environmental enrichment
Grants & Funding:
Active NIH grants include studies on:
- Sperm miRNAs in trauma transmission (2020-2024)
- Paternal stress effects across generations (2015-2020)
Professional Activities:
- NIH Study Section reviewer (2019)
- Member, Tufts Cancer Center (2006-2015)
- Program Director, Biochemistry Program (2001-2020)
Labs/Teams:
His lab collaborates on projects involving:
- Mouse behavioral models
- Epigenetic analysis techniques
- 3D tissue models for cancer research
