Graham C. Burdge

Dr. Graham C. Burdge is a researcher at the University of Southampton specializing in epigenetic mechanisms of transgenerational inheritance. His work examines how prenatal nutritional conditions induce phenotypic changes transmitted across generations through molecular pathways.

Research focuses on nutritional programming and epigenetic transmission, particularly:

• Effects of dietary protein restriction during pregnancy
• Hepatic transcriptome alterations in offspring
• Mechanisms of phenotypic plasticity across generations
• Developmental origins of metabolic disease

His publications reveal consistent patterns in rodent models demonstrating sex-specific epigenetic modifications in liver gene expression following maternal dietary interventions. Work emphasizes the Developmental Origins of Health and Disease (DOHaD) framework, showing progressive transgenerational deterioration in metabolic phenotypes.

Collaborates extensively with Emeritus Professor Mark Hanson and international researchers including Peter D. Gluckman, with funding historically from the Biotechnology & Biological Sciences Research Council.