معرفی
Susan Gueble, MD, PhD, is an Assistant Professor of Therapeutic Radiology at Yale School of Medicine. She completed her medical training through Yale's Medical Scientist Training Program (MSTP), earning both MD and PhD degrees, followed by residency in radiation oncology at Yale-New Haven Hospital. Her clinical practice focuses on treating patients with gynecologic, prostate, and genitourinary malignancies, primarily at the Trumbull, CT location.
Dr. Gueble's research centers on DNA damage response pathways and novel DNA modifying agents, with the goal of developing more effective cancer treatments. Her work has significant implications for understanding and overcoming drug resistance in brain cancers, particularly gliomas. She has established a robust research program that bridges radiation oncology with molecular cancer biology, focusing on how DNA repair mechanisms can be targeted therapeutically.
Her publication record demonstrates expertise across multiple cancer types and therapeutic approaches, with particular emphasis on alkylating agents, PARP inhibitors, and mechanisms of drug resistance. Dr. Gueble has made notable contributions to understanding how oncometabolites regulate DNA damage response and how novel compounds like KL-50 can target drug-resistant brain cancers.
- NIH Director's Early Independence Award (2023)
- Spector Family Fund for Clinical Research and Investigation Award (2023)
- RSNA Roentgen Resident/Fellow Research Award (2023)
- B. Leonard Holman Research Pathway (2020)
Dr. Gueble maintains active collaborations with leading researchers including Peter M. Glazer, Ranjit S. Bindra, and Juan Vasquez. She is a member of professional organizations such as the American Society for Radiation Oncology (2019-present), American Brachytherapy Society (2023-present), and Radiation Research Society (2023-present). Her research has been published in high-impact journals including Science, Journal of the American Chemical Society, and Neuro-Oncology, reflecting the translational significance of her work from basic mechanisms to potential clinical applications.