معرفی
Subramaniam Malarkannan, PhD is a Professor and Gardetto Chair for Immunology and Immunotherapy at the Medical College of Wisconsin. He holds joint appointments in the Department of Microbiology & Immunology, Medicine (Hematology and Oncology), and is a Senior Investigator at Versiti Blood Research Institute. His research focuses on natural killer (NK) cell biology, with emphasis on immunotherapy development, signaling pathways regulation, and metabolic reprogramming in cancer contexts.
Malarkannan earned his PhD in Human T Cell Activation from Madurai Kamaraj University (1992). His lab investigates three core areas: 1) CAR-engineered NK cells for cancer therapy with focus on cytokine release syndrome mitigation, 2) spatial-temporal signaling mechanisms via scaffolding proteins like IQGAP1, and 3) metabolic shifts during NK cell activation. Recent work has identified novel signaling pathways critical for cytokine production and cytotoxicity separation.
His publications (2022-2025) emphasize translational research in supercharged NK cell therapies, immune microenvironment analysis in pancreatic cancer, and understanding ALS pathogenesis through cytotoxic immune mechanisms. The lab maintains active collaborations across immunology, oncology, and cardiovasculature fields.
Key technologies employed include single-cell transcriptomics, genetically modified mouse models, and in vivo tumor efficacy studies. Current efforts aim to develop CRS-free CAR therapies and define metabolic dependencies in immunotherapeutic contexts.
