معرفی
Stina Wickström is a Principal Researcher and Docent at the Department of Oncology-Pathology, Karolinska Institutet, with a focus on immunology and cancer immunotherapy. She completed her PhD in 2016 at the Department of Microbiology, Tumor and Cell Biology, KI, and was promoted to Assistant Professor (2020-2024) before becoming Docent in 2024.
- PhD: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet (2016)
- Docent: Karolinska Institutet (2024)
Her research centers on adoptive cell therapy (ACT), particularly engineering natural killer (NK) cells and CAR T cells to overcome tumor immune tolerance. Key areas include oxidative stress in tumor microenvironment, regulatory T cell interactions, and CD137/CD137L downregulation mechanisms. She investigates pathways like IL-6/STAT3 and Nrf2 to enhance immune cell functionality against cancers such as ovarian, cervical, and melanoma.
Her 15 most recent publications (2024-2010) explore NK cell biology, TIL expansion, CAR T cell dysfunction, and macrophage-mediated immune suppression. Themes include tumor immune tolerance mechanisms, cytokine signaling, and innovative cell therapy techniques to counteract oxidative stress.
She leads grants from the Swedish Research Council (2024-2026) and Swedish Cancer Society (2023) for personalized cellular immunotherapy in gynecological cancers. Her work aims to expand ACT for patients with recurrent cervical/ovarian cancer by enhancing ROS tolerance in immune cells.
