معرفی
Jakob Michaëlsson is a Principal Researcher and Associate Professor at Karolinska Institutet, affiliated with the Department of Medicine, Huddinge, and leading the Michaelsson research group at the Center for Infectious Medicine (CIM). His work focuses on innate lymphoid cells (ILCs), Natural Killer (NK) cells, and CD8+ T cells across human lifespan stages, with emphasis on their roles in cancer, infections, and immune system development.
He earned his PhD in 2002 from Karolinska Institutet and conducted postdoctoral research at UC San Francisco. His current projects include fetal ILC development, tissue-resident NK cells in lung tumors, and clonal dynamics of memory T cells. Collaborations include Team Marquardt (HERM) and Dr. Jeff Mold (Frisén lab).
Methodologies include advanced flow cytometry (29-color), spatial transcriptomics, and single-cell RNA sequencing. Key goals are translating immunological insights into therapies for cancer and infectious diseases. Funding sources include the Swedish Research Council, Swedish Cancer Society, and Karolinska Institutet.
His lab's work explores immune cell heterogeneity, functional specialization, and therapeutic targeting, with a focus on NK cell plasticity and tumor infiltration patterns.
