معرفی
Steven Artandi, MD, PhD serves as the Laurie Kraus Lacob Director of the Stanford Cancer Institute, the Jerome and Daisy Low Gilbert Professor of Medicine and Biochemistry at Stanford University, Senior Associate Dean for Cancer Programs for Stanford School of Medicine, and Chief Cancer Officer for Stanford Health Care. His academic appointments include Professor in Medicine (Hematology) and Biochemistry, and membership in Bio-X, the Maternal & Child Health Research Institute (MCHRI), and the Stanford Cancer Institute.
Dr. Artandi's research focuses on telomeres and telomerase, exploring their critical roles in cancer development, aging, and stem cell function. His laboratory investigates how telomere shortening influences disease processes and how telomerase, beyond its role in telomere elongation, regulates stem cells. His work has revealed novel mechanisms by which telomerase endows cells with immortal growth properties and how developing cancers overcome critical barriers during carcinogenesis. His research spans molecular, cellular, and organismal levels, employing diverse genetic and biochemical approaches to understand telomerase function.
His recent work demonstrates catalytic-activity-independent roles for TERT in stem cell competition, TERT's contribution to tissue regeneration after radiation damage, and advanced methods for telomere measurement that distinguish healthy aging from disease. His research has significant implications for understanding cancer origins, developing regenerative therapies, and creating clinical biomarkers for aging and disease.
- Outstanding Investigator Award from the National Cancer Institute
- Fellow, American Association for the Advancement of Science (AAAS) (2008)
- Elected Member, American Society for Clinical Investigation (2008)
- Elected Member, Association of American Physicians (2015)
- Member, American Association for the Advancement of Science (2019)
Dr. Artandi actively mentors students across multiple programs, serving as Med Scholar Project Advisor, Doctoral Dissertation Reader, Postdoctoral Faculty Sponsor, and Doctoral Dissertation Advisor. He is involved in numerous grant-funded research projects focused on telomere biology, cancer development, and stem cell function. His laboratory collaborates extensively with other researchers at Stanford and beyond, contributing to large-scale projects like the Tabula Sapiens single-cell atlas.
The Artandi Laboratory maintains active research programs investigating telomerase function in various tissue contexts, stem cell dynamics, and cancer development mechanisms. The lab employs cutting-edge techniques including lineage tracing from the Tert locus, single-cell analysis, and advanced genomic approaches to study telomere biology in health and disease.
