Steve Goldstein

Steve Goldstein serves as Vice Chancellor for Health Affairs and Professor at the University of California, Irvine (UCI). His academic appointments span multiple departments, including Physiology and Biophysics, Pediatrics, and Pharmaceutical Sciences (School of Pharmacy & Pharmaceutical Sciences). Dr. Goldstein's research focuses on voltage-gated ion channels, particularly Kv1.1 and Hv1, and their roles in neurological and immunological diseases.

Research Highlights:

• Discovery of AETX-K, a sea anemone toxin with picomolar affinity for Kv1.1 channels
• Mechanistic studies of toxin-channel interactions through NMR and electrophysiology
• Therapeutic applications for epilepsy and cardiorespiratory disorders
• Investigation of SUMOylation in regulating sodium and potassium channels

Grants:

• R01 HL159711 (NIH/NHLBI)
• R33 AT012544 (NIH/NCCIH)
• U54 GM087519 (NIH/NIGMS)
• R01 GM111716 (NIH/NIGMS)
• R61 AT012544 (NIH/NCCIH)