معرفی
Dr. Stephen Derek Brealey is a Research Fellow and Trial Manager in the School of Health Sciences at the University of York. With a background in Diagnostic Radiography and Health Services Research, he specializes in managing multi-center pragmatic randomized trials focused on musculoskeletal conditions, particularly orthopedic surgical interventions in secondary care settings.
Dr. Brealey holds a PhD and BSc, though specific details about his educational institutions and graduation years are not provided in the available information.
Dr. Brealey's primary research focuses on orthopedic surgical trials, with particular expertise in managing large-scale pragmatic randomized controlled trials. His work centers on comparative effectiveness research for various musculoskeletal conditions including pilon fractures of the ankle, displaced fractures of the distal clavicle, proximal humerus fractures, scaphoid waist fractures, and frozen shoulder. He has led or contributed to numerous NIHR-funded trials through the Health Technology Assessment Programme, examining both clinical and cost-effectiveness of surgical versus non-surgical interventions. His methodological interests include trial design, implementation science, and health economics aspects of surgical interventions.
Analysis of Dr. Brealey's recent publications reveals a strong focus on pragmatic clinical trials in orthopedic surgery, with particular emphasis on comparative effectiveness research. His work spans methodological advancements in trial design, long-term outcomes of surgical interventions, implementation of evidence into practice, and patient-centered outcomes. A notable trend is his increasing involvement in geriatric care transitions research through the PACT program, while maintaining his core focus on musculoskeletal conditions. His publications consistently address both clinical effectiveness and cost-effectiveness, reflecting a comprehensive approach to healthcare evaluation.
While specific scientific awards are not documented in the available information, Dr. Brealey's extensive publication record in high-impact journals and leadership of multiple NIHR-funded trials represents significant recognition of his expertise in clinical trial management and orthopedic research.
Dr. Brealey has served as Trial Manager for several major research projects including ACTIVE, DIDACT, ProFHER, PACT, RAPSODI, SWIFFT, and UK FROST trials. These projects have received substantial funding primarily from the NIHR Health Technology Assessment Programme. His role involves overseeing the operational aspects of these complex multicenter trials, ensuring methodological rigor while addressing practical implementation challenges in real-world healthcare settings. His collaborative approach is evident through his extensive co-authorship network across multiple institutions.
Dr. Brealey works within the Trials and Statistics research group at the University of York's School of Health Sciences. His work involves close collaboration with orthopedic surgeons, healthcare economists, qualitative researchers, and clinical trial methodologists across multiple UK hospitals and research institutions. He has been instrumental in developing and implementing standardized protocols for surgical trials while addressing recruitment challenges and ensuring high-quality data collection across diverse clinical settings.
