معرفی
Dr. Stephanie Halene is the Arthur H and Isabel Bunker Professor of Medicine (Hematology) and Professor of Pathology at Yale School of Medicine. She serves as Chief of Hematology at Yale Cancer Center and Smilow Cancer Hospital, Assistant Medical Director of CRSL at Yale Cancer Center, and Director of the DeLuca Center for Innovation in Hematology Research.
Dr. Halene received her MD from Eberhard-Karls-University in Tübingen, Germany. Her training includes a postdoctoral fellowship with Donald B. Kohn at Children's Hospital Los Angeles, residency in internal medicine at Yale New Haven Hospital, and fellowship in hematology/oncology at Yale. She joined the Yale School of Medicine faculty as an assistant professor in 2010, was promoted to associate professor in 2016, and became Chief of the Section of Hematology in 2020.
Dr. Halene's research focuses on hematopoiesis and myelopoiesis, particularly how mutations in splicing factors and RNA modifications contribute to hematologic malignancies such as myelodysplasia and leukemia. Her laboratory has developed the first efficient xenotransplantation model in humanized mice to study myelodysplasia. Her work spans molecular biology, RNA biology, and translational hematology, with applications to understanding and treating blood disorders.
Dr. Halene's publications demonstrate a strong focus on RNA modifications, splicing factor mutations, and their roles in hematologic malignancies. Her research integrates cutting-edge technologies including single-cell analysis, xenotransplantation models, and multi-omic approaches to unravel disease mechanisms and develop novel therapeutics.
- Elected Member, Connecticut Academy of Science and Engineering (2024)
- Recipient of the "2nd Century of Women: Emerging Leaders in Internal Medicine" Award (2022)
- Elected Member, Interurban Clinical Club (2019)
- Sir William Osler Young Investigator Award (2015)
- Career Development Award, Yale School of Medicine (2010)
As Director of the DeLuca Center for Innovation in Hematology Research, Dr. Halene oversees a comprehensive biospecimen bank and administers pilot and career development grants to advance discoveries in hematologic malignancies. She also co-directs the Mouse Modeling Core of the Yale Cooperative Center of Excellence in Hematology, providing researchers with access to the latest technologies for hematologic studies in animal models.
Dr. Halene leads the Halene Laboratory, which focuses on myeloid malignancies and hematopoiesis. The lab maintains the Hematology Tissue Bank, providing researchers access to critical patient samples for studying hematologic diseases. She also serves on the External Advisory Board for the Cellular & Molecular Biology Masters Program and is actively involved in clinical care, focusing on both malignant and classical hematologic disorders.